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This allowed any brand of freewheel to be mounted on any brand of hub.

Dr Neil Ebenezer, director of research, policy and innovation at Fight for Sight, a British charity dedicated to pioneering eye research to prevent sight loss, said: “We are delighted at the success of researchers at Newcastle University in developing 3D printing of corneas using human tissue.

“This research highlights the significant progress that has been made in this area and this study is important in bringing us one step closer to reducing the need for donor corneas, which would positively impact some patients living with sight loss.

Stem cells were then added and left to grow to create a cornea which is theoretically ready for transplantation.

Up to 10 million people worldwide require surgery to prevent corneal blindness as a result of diseases, while another 5 million suffer total blindness due to corneal scarring.

With a Freehub, on the other hand, once the sprockets are removed, the right hub flange is accessible for replacement of a broken spoke. The sprockets are commonly sold as a set, called a "cassette".

Sprockets in many cassettes are held together by three small bolts or rivets for ease of installation.

“Many teams across the world have been chasing the ideal bio-ink to make this process feasible," said Che Connon, professor of tissue engineering at Newcastle University, who led the study.

“Our unique gel - a combination of alginate and collagen - keeps the stem cells alive whilst producing a material which is stiff enough to hold its shape but soft enough to be squeezed out the nozzle of a 3D printer.

“However, it is important to note that this is still years away from potentially being available to patients and it is still vitally important that people continue to donate corneal tissue for transplant as there is a shortage within the UK.

Traditional rear hubs came with a standardized set of threads to which a standard freewheel/sprocket cluster could be screwed on.

Some lockring tools have a long handle, others, like the one in the photo below, have a hexagonal fitting like a nut, which can either be turned with a large wrench or clamped in a vise.

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