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But “that doesn’t eliminate the need for space that can be a springboard for younger high potential companies that don’t yet have that same ability to pay,” Rosin said.

Significant increases in lab rents “could force some outstanding start-ups to make the difficult decision to leave Philly and the University City destination, where we’d like a high density of talent and frequent interactions with Penn.

“There’s a need for lab space [compared to] more than five years ago.

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They both worked together at the glamorous Enterprise Rent-A-Car San Jose Airport location where they rented cars to weary business travelers.

Kim was an Assistant Manager and Brad was one of her employees.

Outsourcing lab managers “was a strategic decision,” Science Center spokeswoman Jeanne Mell said.

By leaving labs to CIC and its “higher level of service,” the center fits better with an “emerging national trend.” Mell said that leaves the center to get out of the lab landlord business and “focus on what we do best,” connecting start-ups and their owners “to our network of investors, subject matter experts, advisors and mentors,” and large companies to help bring startup products to market.

Among those friendships were Kim's and Brad's, whose organic connection grew into a subtle attraction, which coworkers loved to tease them both about individually.

Over a period of time, Brad ended up accepting another job in San Francisco to work at First Republic Bank.

They hustled during their 10-12 hour shifts, which consisted of constant crowd control, high sales expectations, and unwavering customer service.

The experience was trying, but nevertheless helped them both grow as young professionals and created strong friendships along the way.

All are city residents who don’t own cars, she told me. This is home,” if her firm and others like it can still find affordable space, Wronko said.

She’s also looking into sites in Delaware, including an ex-Du Pont site that the state is helping redevelop for start-ups. Corporate labs in Montgomery and Bucks Counties have been repurposed for small biotech firms, said real estate broker Paul Touhey, senior vice president at CBRE’s Philadelphia office.

Bio Labs is headed by Johannes Fruehauf, partner in Bio Innovation Capital, of Boston.

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